UMR 866 – DMEM
Muscle Dynamics and Metabolism (UMR 866)
Research Areas: Physiology, Cellular and Molecular Biology
Director: Vincent OLLENDORFF
Co-Director: FRANÇOIS CASAS
The Muscle Remodeling and Signaling team is part of UMR 866 Muscle Dynamics and Metabolism, led by Vincent Ollendorff. This team includes a group of faculty members from the UFR STAPS.
- Guillaume PY, Assistant Professor with a Doctorate in Research (HDR)
- Christelle RAMONATXO, Assistant Professor (MCF) with a Doctorate in Research (HDR)
- Thomas BRIOCHE, Assistant Professor
Areas of Focus
Due to its mass and metabolic characteristics, skeletal muscle exhibits remarkable adaptive capabilities. The team’s project aims to identify the factors that control muscle plasticity—specifically, the balance between atrophy and hypertrophy—as well as the mechanisms involved in maintaining muscle mass and function. The team’s objectives are:
- the validation of strategies (nutrition, physical activity, pharmacological treatment, genetic predisposition) that may improve muscle integrity and function.
- the characterization of muscle plasticity within the contractile unit itself in response to strength, endurance, and/or hypoxia training
- the molecular and phenotypic characterization of factors involved in the regulation of muscle mass, with a focus on the translation factor eIF3f, the stress protein REDD1, the ubiquitin-proteasome system regulator MAFbx, and the growth factor myostatin.
