UMR 866 – DMEM
Muscle Dynamics and Metabolism (UMR 866)
Research areas: Physiology, Cellular and Molecular Biology
Director: Vincent OLLENDORFF
Co-Director: FRANÇOIS CASAS
The Muscle Remodeling and Signaling team is part of UMR 866 Muscle Dynamics and Metabolism, directed by Vincent Ollendorff. This team includes a group of faculty members from the UFR STAPS.
- Guillaume PY, Associate Professor
- Christelle RAMONATXO, Associate Professor
- Thomas BRIOCHE, Associate Professor
Areas of focus
Due to its mass and metabolic characteristics, skeletal muscle has remarkable adaptive capabilities. The team's project aims to identify the factors controlling muscle plasticity, specifically the balance between atrophy and hypertrophy, as well as the elements involved in maintaining muscle mass and function. The team's objectives are:
- the validation of strategies (nutrition, physical activity, pharmacological treatment, genetic predisposition) likely to improve muscle integrity and function.
- the characterization of muscle plasticity within the contractile unit itself in response to strength training, endurance training, and/or hypoxia
- Molecular and phenotypic characterization of factors involved in muscle mass regulation, with a focus on the translation factor eIF3f, the stress protein REDD1, the ubiquitin-proteasome system regulator MAFbx, and the growth factor myostatin.
