UMR 866 - Muscle Dynamics and Metabolism Team
Muscle Dynamics and Metabolism (UMR 866)
Research sectors: Physiology, Cellular and Molecular Biology
Director: Vincent OLLENDORFF
Co-Director: Guillaume PY
The Muscle Remodeling and Signaling team is part of UMR 866 Dynamique du Muscle et Métabolisme, headed by Vincent Ollendorff, and includes a group of teacher-researchers from UFR STAPS.
- Robin CANDAU, PR
- Angèle CHOPARD, PR
- François FAVIER, MCF-HDR
- Guillaume PY, MCF-HDR
- Christelle RAMONATXO, MCF-HDR
- Thomas BRIOCHE, MCF
Work areas
Because of its mass and metabolic characteristics, skeletal muscle is surprisingly adaptable. The team's project aims to identify the factors controlling muscle plasticity, and more specifically the atrophy/hypertrophy balance, as well as the elements involved in maintaining muscle mass and function. The team's objectives are :
- validation of strategies (nutrition, physical activity, pharmacological treatment, genetic predisposition) likely to improve muscle integrity and function.
- characterization of muscle plasticity within the contractile unit in response to strength, endurance and/or hypoxia training
- molecular and phenotypic characterization of factors involved in muscle mass regulation, with preferred targets being the translation factor eIF3f, the stress protein REDD1, a regulator of the ubiquitin-proteasome system MAFbx and the growth factor myostatin.
